Enhanced porphyrin-based fluorescence imaging-guided photodynamic/photothermal synergistic cancer therapy by mitochondrial targeting

Mitochondria are the power plants of cell and play key roles in activating apoptotic pathway cancer cells, which readily susceptible to cytotoxic reactive oxygen species temperature elevations. Herein, we develop a “nanomissile” that targets mitochondria enhance tumor treatment effects by facilitating mitochondrial dysfunction releasing cytochrome C activate cells under 650-nm laser irradiation. Porphyrin-grafted polydopamine nanomaterial (PTPF-MitP) is designed as nanomissile, with integrated O2-evolving photodynamic therapy moderate photothermal therapy, can selectively deliver through targeting unit, MitP. The cytotoxicity PTPF-MitP human lung twice high PTPF does not have units. In addition, it represents realtime visualization highly efficient for sites vivo. This development viable strategy therapy.